AI-assisted preparation covered Figures 1–4, Supplementary Figures S1 and S2, and the graphical abstract. Assistance included creation of individual figure components and plotting code. The authors assembled and edited components in Adobe Illustrator 2026 (version 30.1, the release line available in February 2026). The supplied Matplotlib 3.10.8 scripts generate the computational plots and graph drawings from the documented model definitions and numerical results; they do not reproduce every subsequent Illustrator layout or presentation edit. Figure 1A is an explanatory schematic rather than patient-derived anatomy. Figure 1C and the graphical abstract represent the same eight-unit reference graph. All plotted values, network connections and numerical annotations must be read as outputs of the stated computational model, not as observations generated or inferred by an image-generation system.

Google Gemini Deep Research (Google; continuously updated web service, exact backend model/build and its release date not documented in the available records) and Anthropic Claude Opus (version 4.6, released 2026-02-05) supported the initial research and methodological review. OpenAI ChatGPT assisted with literature checks, code review, manuscript editing and figure preparation. For the February 2026 version context, a publicly available OpenAI model was GPT-5.2 (version 5.2, released 2025-12-11); the exact model used in individual ChatGPT sessions was not documented in the available records, so this release information is a temporal reference rather than a verified session identifier. AI-assisted figure preparation covered Figures 1–4, Supplementary Figures S1 and S2, and the graphical abstract, including assistance in creating individual components and plotting code. The authors assembled and edited these components in Adobe Illustrator 2026 (version 30.1, the release line available in February 2026). The quantitative plots and network representations derive from the accompanying executable Python analyses and model specifications, rather than AI-estimated numerical values. The authors reviewed the final figures and take responsibility for the code, references, interpretation and manuscript content.
